Even worse, it leaves you down a Jumbo Cactuar, and once you've shown your ruthlessness, the remaining two players will have no qualms about responding Escape Tunnel is likely to be another popular interaction
Obviously, if people start playing a ton of anti-creature cards that match up well against Izzet, we could also go the other way, starting as a Thousand-Year deck and transforming into creatures later
Dread Presence and Retreat to Hagra are a good start, and Liliana of the Dark Realms is a strong planeswalker here
If you want a second easy path, Krenko, Mob Boss is another classic starter option, though the Krenko decklist ranked up above is tuned for cEDH
Generally, in Commander, you have three opponents who have all sorts of targeted removal just waiting to be thrown out to any player who gets the tiniest bit of an advantage in the game
It also excludes legendary creatures who would be great commanders, but not necessarily work as one of the 99