Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17

InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17

Glabrescione B impairs its activity by interfering with Gli1-DNA interaction

Prophylactic treatment of adjuvant-induced arthritis rats with auranofin results in a slight reduction in paw edema

InChiKey: VYQXIUVIYICVCM-UHFFFAOYSA-N

38(6):1260-5

Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride InChi: InChI=1S/C20H27NO3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21-24)11-12-20(17Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP competitive Polo like kinase 1 (PLK1) inhibitor with an IC50 of 0. 87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. Product information