Lumateperone tosylate y-1-Methoxyaporphine P53R3 induces p53-dependent antiproliferative effects

P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1

InChiKey: UDKVBVICMUEIKS-GGMCWBHBSA-N

and RPL6 proteins

Methysticin triggers the most profound inducing effect on CYP1A1

ClH/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18

Lumateperone tosylate y-1-Methoxyaporphine P53R3 induces p53-dependent antiproliferative effectsLumateperone tosylate (ITI 007 tosylate) is a 5 HT2A receptor antagonist (Ki = 0. 54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). IC50 value: 0. 54 nM (Ki, for 5 HT2A receptor )Target: 5 HT2A receptorLumateperone also possesses affinity for the D1 receptor (Ki = 52 nM) and weak affinity for the 1A and 1B adrenergic receptors (Ki = 173 nM at 1) and D4