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which inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM
is a potent and selective Topoisomerase I inhibitor
InChiKey: HIXSPVQXXDULHS-UHFFFAOYSA-N
PMCID: PMC4046644
4-oxadiazol-3-yl)benzamide
(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 which inhibits ATR immunoprecipitated from(Z) 4 Hydroxytamoxifen (also called 4 OH TAM), CAS No. 68047 06 3, was previously characterized as an Estrogen Receptor antagonist and now found to improve genome editing specificity in CRISPR mediated gene editing. It can activate intein linked inactive Cas9, reducing off target. Such system has ~25 fold higher specificity than wtCas9. (Z) 4 Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency
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