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HIF-C2 was used at 10 µM final concentration in vitro and in cellular assays
Carpenter C
Smiles: CC(C)[C@H]1CC2=CC(OCCCOC)=C(C=C2C2=CC(=O)C(=CN21)C(O)=O)OC
Chemical Name: (4-(4-{[2-(4-chlorophenyl)-4
and 18) makes tumors shrinking even after the treatment and finally revealing complete regression
G007-LK B-PS HIF-C2 was used at 10G007 LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1 2 inhibitor. G007 LK displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007 LK was first discovered by Dr. Stefan Krauss's team. Product information CAS Number: 1380672 07 0 Molecular Weight: 529. 96 Formula:
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