TAK-715 odiamide hydrate MX-1 and DLD-1 with ED75

MX-1 and DLD-1 with ED75 from 4

Acetazolamide D3 is deuterium labeled Acetazolamide

Smiles: NCCCC[C@H](N[C@@H](CCC1C=CC=CC=1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O

for both the resting and depolarized states

Chemical Name: (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide

TAK-715 odiamide hydrate MX-1 and DLD-1 with ED75TAK 715 is a potent p38 MAPK inhibitor. which displays potent inhibitory activity (inhibition of p38alpha, IC50 = 7. 1 nM; LPS stimulated release of TNF alpha from THP 1, IC50 = 48 nM; LPS induced TNF alpha production in mice, 87. 6% inhibition at 10 mg kg, po) and no inhibitory activity for major CYPs, including CYP3A4. TAK 715 was selected as a clinical candidate and is now under clinical investigation for the treatment of RA. Product information