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InChiKey: ZTUJNJAKTLHBEX-UHFFFAOYSA-N
InChi: InChI=1S/C16H17N3O4S
Trigenolline
2010 Oct 30 [updated 2013 Feb 28]
19(22):6768-78
Marein Catalog No.:M13748-10 InChiKey: ZTUJNJAKTLHBEX-UHFFFAOYSA-NMarein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK AMPK GLUT1 to promote glucose uptake, through IRS Akt GSK 3 to increase glycogen synthesis, and through Akt FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 M. Marein has beneficial antioxidative,
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