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arrest of the S/G2 phase of the cell cycle
Horváth C
Indiplon-MR was unapprovable and may require further evaluation
460(4):903-8
Smiles: CC1=C(C2=CC=C(O)C=C2N1C1C=CC(=CC=1)OC)[N+]([O-])=O
PP1 (Givinostat) arrest of the S/G2 phasePP1 is a potent and selective Src family protein tyrosine kinase inhibitor. PP1 effectively blocks TGF beta1 induced cell migration and invasion in both established and primary carcinoma cells. PP1 blocks TGF beta1 mediated cellular responses by direct and differential inhibition of type I and type II TGF beta receptors. PP1 was also found to potentiate tumor suppressive effect of connexin 32 gene in renal cancer cells. Product information CAS Number:
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