The main difference from other card games is that its mostly single-player, and that means no additional costs to the game besides the base cost
Infect commanders generally revolve around proliferate or poison counters directly, or combat to allow for creatures with infect to attack the opponent directly, oftentimes finding ways around potential blockers
Starts at 4/4) 0: One 3/3 (Huatli, Warrior Poet) -1: One 4/4 (Vivien on the Hunt) 6-mana: +1: One 2/2 with major upside (Vraska, Relic Seeker, Ugin, the Ineffable, Liliana, Dreadhorde general), three 1/1s (Elspeth, Suns Champion), two non-defensive 3/1s (Chandra, Flamecaller) 0: Two 2/2s with minor upside
And critically, when you collect a card from Deluxe Pack: ex, it counts toward your Deluxe Pack: ex collection, but not toward the collection from which it derived
Using this card as your Bench Pokemon can give you a significant advantage in games, as its ability, Restart, allows you to maintain the number of the cards in your hands to at least three for every turn
Collectors also care about early print differences