Tolnaftate (D7) automerism) The potency of pan-RAS-IN-1 correlates

The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range

InChi: InChI=1S/C24H24N2O7/c1-3-30-24(29)15(2)33-19-6-4-5-18-17(19)9-10-26(23(18)28)14-22(27)25-16-7-8-20-21(13-16)32-12-11-31-20/h4-10

InChi: InChI=1S/C47H74N16O10/c1-4-25(2)37(45(72)73)61-41(68)32(14-8-20-55-47(52)53)58-38(65)26(3)57-40(67)31(13-7-19-54-46(50)51)59-42(69)34-15-9-21-62(34)44(71)35-16-10-22-63(35)43(70)33(17-18-36(49)64)60-39(66)29(48)23-27-24-56-30-12-6-5-11-28(27)30/h5-6

is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity

InChiKey: HCTLWQSYGIBOFM-UHFFFAOYSA-N

Tolnaftate (D7) automerism) The potency of pan-RAS-IN-1 correlatesTolnaftate D7 (NP 27 D7) is the deuterium labeled Tolnaftate. Tolnaftate (NP 27) is a synthetic thiocarbamate used as an anti fungal agent. Product information CAS Number: 1329835 64 4 Molecular Weight: 314. 45 Formula: C19H17NOS Chemical Name: N methyl N (3 methylphenyl) 1 [(1,3,4,5,6,7,8 H)naphthalen 2 yloxy]methanethioamide Smiles: [2H]C1C(OC(=S)N(C)C2=CC(C)=CC=C2)=C([2H])C2=C(C=1[2H])C([2H])=C([2H])C([2H])=C2[2H] InChiKey: FUSNMLFNXJSCDI