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SGI-110 Size:Solid 10 mg It has Gram-negative coverage which

SKU: 21138090273

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Description

It has Gram-negative coverage which includes Pseudomonas aeruginosa but limited Gram-positive coverage

CAS Number: 2752-65-0

Epub 2017 Jan 24

Mobashery S

(2013) ACS Chem Biol

SGI-110 Size:Solid 10 mg It has Gram-negative coverage whichGuadecitabine, aslo known as SGI 110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI 110 inhibits DNA methyltransferase, thereby causing genome wide and non specific hypomethylation and inducing cell cycle arrest at S phase. This agent is resistant to cytidine deaminase, hence may

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