23-Hydroxybetulinic acid Size:Contact [email protected] for quotation InChi: InChI=1S/C24H32N6O6/c25-10-1-3-21-5-7-22(8-6-21)29-24(32)4-2-11-27-23(31)9-13-33-15-17-35-19-20-36-18-16-34-14-12-28-30-26/h5-8H

InChi: InChI=1S/C24H32N6O6/c25-10-1-3-21-5-7-22(8-6-21)29-24(32)4-2-11-27-23(31)9-13-33-15-17-35-19-20-36-18-16-34-14-12-28-30-26/h5-8H

J Am Acad Dermatol

InChiKey: ZNYNDJDSFMRJPS-BHMVLGHDSA-N

PMID: 32812660

Barasertib is a prodrug and will be converted rapidly to the active drug AZD1152-HQPA in human plasma

23-Hydroxybetulinic acid Size:Contact [email protected] for quotation InChi: InChI=1S/C24H32N6O6/c25-10-1-3-21-5-7-22(8-6-21)29-24(32)4-2-11-27-23(31)9-13-33-15-17-35-19-20-36-18-16-34-14-12-28-30-26/h5-8H23 hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity. In vitro: 23 hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78. 5, 80, and 94. 8 uM, respectively. 23 hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23 hydroxybetulinic acid disrupts mitochondrial membrane