ML-329 - CAS# 19992-50-8 Catalog No.:M6543-2 Novel SHP-1 inhibitors tyrosine phosphatase

Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents

Evidence that PERK is implicated in tumorigenesis and cancer cell survival stimulated our search for small molecule inhibitors

G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes

VEGFR-3 and PDGFR-β with IC50s of 0

is a potent autophagy inhibitor and TLR9 inhibitor

ML-329 - CAS# 19992-50-8 Catalog No.:M6543-2 Novel SHP-1 inhibitors tyrosine phosphataseML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.