PF-00562271 EG5-Tos In an mTOR kinase immunoprecipitation

In an mTOR kinase immunoprecipitation assay using cell lysates

WIN-55212-2 mesylate inhibition of 50 mm K+-evoked CGRP release is not reversed by antagonists of cannabinoid type 1 (CB1) receptor

respectively

and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2)

507 was used at 1-5 µM final concentration in various in vitro assays

PF-00562271 EG5-Tos In an mTOR kinase immunoprecipitationPF 562271, also known as PF 562, 271 and PF 271, is an orally bioavailable small molecule and ATP competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF 562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. Product information CAS Number: 717907 75 0 Molecular Weight: 507. 49