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Chemical Name: (4E)-6-[4-hydroxy-6-(¹³C
Pranlukast shows competitive antagonism against the LTC4- and LTD4-induced contractions of guinea pig trachea and lung parenchymal strips with a pA2 range of 7
It is moderately toxic to mammals
InChiKey: QUEWKNBREKFLND-HYQUBYKOSA-N
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexan-2-one
TRAM 39 13081 Chemical Name: (4E)-6-[4-hydroxy-6-(¹³CTRAM 39, 2 (2 chlorophenyl) 2, 2 diphenyl acetonitrile, is a potent, synthetic, selective inhibitor of intermediate conductance Ca2+ activated K+channels. TRAM 39 selectively block K Ca3 but do not inhibit other Ca2+ activated K+channels.[1,3] Intermediate conductance Ca2 activated K channels are the product of the IKCa1 genes and are important in regulating the membrane potential of colonic epithelial cells, and lymphocytes. The IKCa1 gene is also
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