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(N-(HETERO)ARYL
is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM
by functionally inhibiting the Jumonji domain-containing demethylase KDM4C
which is an enzyme that controls the generation of two cytokines
Formula: C32H40Br2N4
LY-2584702 free base Size:Solid 10 mg (N-(HETERO)ARYLLY 2584702, also known as LYS6K2, is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine threonine kinase, acts downstream of PIP3 and
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