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Formula: C25H22ClN5O2S
and in vivo in monkeys and humans
Fatostatin A was used at 10-20 µM in vitro
is an immunoproteasome inhibitor
Boergermann JH
PF-04979064 - PI3K/mTOR Dual Inhibitor. CAS# 1220699-06-8 hylase Formula: C25H22ClN5O2SPF 04979064, CAS No. 1220699 06 8, is a highly potent and orally bioavailable PI3K mTOR dual inhibitor developed through structure based drug design. It inhibited mTOR, PI3K, , and isoforms and AKT phosphorylation with IC50 as 2. 64 nM, 0. 395 nM, 0. 111 nM, 0. 122 nM and 28. 3 nM, respectively. PF 04979064 exhibited cellular potency with an IC50 of 9. 1 nM in a BT20 cell assay. PF 04979064 exhibited excellent in vitro potency, very good solubility,
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