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OSU-03012 completely suppress cell growth in a diverse range of tumor cell lines at concentrations of 3–5 μm
SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM
J Clin Invest
(2009) Cell Stem Cell 4(1)
Formula: C18H19FN2O4S
MG-132 463518 OSU-03012 completely suppress cell growthMG132 is a specific, potent, reversible, and cell permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c Jun N terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF B activation with an IC50 of 3 M and prevents secretase cleavage. MG 132