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LGK974 potently inhibits Wnt signaling in vitro and in vivo
placebo-controlled Phase 1/2a trial for patients with open angle glaucoma or ocular hypertension
Smiles: CN1C(=NC2=CC=CC=C12)C1C=C2C(N=C(CCC)N2CC2=CC=C(C=C2)C2=CC=CC=C2C(O)=O)=C(C)C=1
InChi: InChI=1S/C6H13N
InChiKey: CPUHORIUXPQCHW-UHFFFAOYSA-N
Istaroxime Catalog No.:M9594-10 LGK974 potently inhibits Wnt signalingIstaroxime, also known as PST 2744, is a positive inotropic agent that mediates its action through inhibition of sodium potassium adenosine triphosphatase (Na+ K+ ATPase). Na+ K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy
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