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Rhein HPC-O-Ph-PEG1-NH-Boc AP-18 reversibly blocks mouse TRPA1

SKU: 77486137291

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Description

AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging

Salubrinal reduces oxidative stress

CAS Number: 1898283-02-7

CCN(CC)C(=O)C1C=CC(=CC=1)C1C=C(NCCCN2CCCCC2)C2=CC=CC=C2N=1

Formula: C17H27N3O7S

Rhein HPC-O-Ph-PEG1-NH-Boc AP-18 reversibly blocks mouse TRPA1Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti inflammatory, antioxidant, anticancer, and antimicrobial activities. IC50 value: Target: In vitro: Rhein (0. 1 and 1 mg mL) evidently suppressed cell proliferation and mitogen activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco 2) but significantly lessened

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