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3T3 fibroblasts
SCR7: a NHEJ inhibitor promotes the efficiency of HDR 4–5-fold for CRISPR editing in both human and mouse cell lines
N106 was used at 10 µM final concentration in vitro and in cellular assays
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CAS Number: 935666-88-9
Canertinib HCl - CAS# 289499-45-2 60273 3T3 fibroblastsCanertinib, also known as CI1033 and PD183805, CAS No. 289499 45 2, is a potent ErbB inhibitor for the treatment of cancer. It is an irreversible tyrosine kinase inhibitor with activity against EGFR (IC50 0. 8 nM), HER 2 (IC50 19 nM) and ErbB 4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can
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