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Ferroptosis is dependent upon intracellular iron
7R)-7-hydroxy-5-methyl-6
290(22):13641-53
6-maleimidohexanoic acid active esters
185(1):634-41
EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 Ferroptosis is dependent upon intracellularEPZ 5676, CAS No. 1380288 87 8, is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S adenosylmethionine. It inhibits proliferation of MLL AF4 rearranged cell line MV4 11 with an IC50 of 9 nM. It reduces H3K79 dimethylation with a cellular IC50 of 2. 6 nM in MV4 11 cells. EPZ 5676 has over 10, 000 fold selectivity against other HMTs. Its superior potency is
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