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LDN193189 or vehicle is applied to mice 5 days post-tumor cell injection before tumors are palpable
Smiles: [O-][N+](=O)C1=CC(/C=N/NC(=O)C2C=C(O)C=C(O)C=2)=CC=C1O
By use of a cell line derived from an Alzheimer’s disease patient
injected intraperitoneally every other day for 1 month) attenuates progression of OA in anterior cruciate ligament transection (ACLT) mice
408(3):297-315
IWP-O1 - CAS# 2074607-48-8 size:10mg solid LDN193189 or vehicle is appliedIWP O1, CAS No. 2074607 48 8, is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling. Additionally, IWP O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors. Product information CAS