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ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21
Voorhees P
2R)-3-(((1S
InChiKey: OTGPYEHFRKGRIZ-UHFFFAOYSA-N
Formula: C17H22ClNO3
PF-03814735 - CAS# 942487-16-3 Catalog No.:M10382-2 ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21PF 03814735 is an orally bioavailable, ATP competitive, reversible small molecule Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor PF 03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine threonine kinases that play essential roles in mitotic checkpoint control during
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