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LY2157299 was usually used at 5-10µM in vitro and cellular assays
Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines
PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase
establishing favorable hydrophobic and hydrogen bonding interactions with the protein’s active-site residues
1998 Feb 26
U0126 hostatin A (TSA) LY2157299 was usually used atU0126 is a potent and selective non competitive inhibitor of MAP kinase. Inhibits MEK 1 and MEK 2 (IC50 values of 0. 07 and 0. 06 M respectively). Product information CAS Number: 109511 58 2 Molecular Weight: 380. 49 Formula: C18H16N6S2 Synonym: U 0126 Related CAS Number: 1173097 76 1 (U0126 EtOH) Chemical Name: bis({amino[(2 aminophenyl)sulfanyl]methylidene})butanedinitrile Smiles: NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N InChiKey: