Emavusertib - CAS# 1801344-14-8 ericin B Chemical Name: (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

Chemical Name: (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine

Smiles: NCCNC(=O)C1=CC=C(Cl)C=N1

is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM

respectively) as well as CYP3A4 metabolism of 7-benzyloxy-4-trifluoromethylcoumarin (BFC) and dibenzylfluorescein (DBF

Chemical Name: 4-(6

Emavusertib - CAS# 1801344-14-8 ericin B Chemical Name: (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholineEmavusertib, also known as CA 4948 is a potent IRAK4 FLT3 inhibitor with anti tumor activity. CA 4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA 4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with