Cladribine - CAS# 4291-63-8 lbutyric acid (4-PBA) a PKC substrate

a PKC substrate

~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B)

It also prevents spinal injury-induced increase of PAR1 and decreases expression of PDE4D

12b-hexadecahydrospiro[naphtho[2'

2020 Feb 3

Cladribine - CAS# 4291-63-8 lbutyric acid (4-PBA) a PKC substrateCladribine is a purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and