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Five mana is steep, and is going to be difficult to find a spot for, but winning via combat damage in a deck that can throw down a half-dozen creatures every turn is a very real outlet that needs to be considered

So long as you can keep it alive and get it to the attack phase, It That Betrays can win games all on its own

The downside is that these events arent (always) free

Running a Sakazuki deck is about imposing your strategy on your opponent, dictating the pace of play, and maintaining board control through efficient removal and versatility

Keening Stone does the same, although it's significantly more expensive to play

Without any modifications, it only takes three combat phases to deal enough poison counters to an opponent to make them lose the game