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PF-05231023 decreases body weight and improves lipid profile in non-human primates and in type 2 diabetic subjects
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo
D'Antuono I
InChi: InChI=1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11
conscious rats
Temsirolimus dzin PF-05231023 decreases body weight andTemsirolimus is an ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine threonine kinase which plays a role in the PI3K AKT pathway that is upregulated in some tumors. Temsirolimus (CCI 779) is an intravenous drug for the treatment of renal cell